Study	Reason for exclusion
Adam 1994	No randomised controlled trial.
Advani 2014	Conference proceeding of Advani 2015.
Advani 2015	Study does not evaluate different anthracycline dosage schedules.
Alba 2004	Difference in chemotherapy other than anthracyclines between intervention and control group.
Bastholt 1996	Cumulative anthracycline dosis of intervention and control group not mentioned.
Berchem 1996	No randomised controlled trial.
Berrak 2001	No randomised controlled trial.
Blomqvist 1993	Heart failure not mentioned.
Budd 2015	Difference in chemotherapy other than anthracyclines between intervention and control group.
Buzdar 2007	No randomised controlled trial.
Carmo‐Pereira 1987	Difference in actually received cumulative anthracycline dosis between intervention and control group.
Carrio 1993	No randomised controlled trial.
Creutzig 2007	Article describes two studies: one is no randomised controlled trial; one does not evaluate different anthracycline dosage schedules, but different anthracycline derivates.
Ditsch 2012	Difference in therapy other than anthracyclines between intervention and control group; difference in cumulative anthracycline dosis between intervention and control group.
Dorup 2004	No randomised controlled trial.
Ehrlich 1979	Difference in chemotherapy other than anthracyclines between intervention and control group; duplicate publication of Sutton 1989.
Eksborg 1997	Number of patients with heart failure not mentioned.
Ewer 1998	No randomised controlled trial.
Gabizon 2008	Cumulative anthracycline dosis of intervention and control group not mentioned; cardiotoxicity not stated for patients with different anthracycline peak doses; pharmacokinetics study.
Gupta 2003	No randomised controlled trial.
Habeshaw 1991	Difference in cumulative anthracycline dosis between intervention and control group
Henderson 2003	Difference in cumulative anthracycline dosis between intervention and control group.
Hochster 1985	No randomised controlled trial.
Hoeltgen 1983	Difference in cumulative anthracycline dosis between intervention and control group.
Horacek 2010	Difference in therapy other than anthracyclines between intervention and control group.
Hubert 2000	Difference in cumulative anthracycline dosis between intervention and control group; similar anthracycline peak dosis and infusion duration between intervention and control group.
Hunault‐Berger 2001	Cumulative anthracycline dosis of intervention and control group not mentioned.
Irwin 1980	Difference in chemotherapy other than anthracyclines between intervention and control group.
ISRCTN 83324925	Ongoing trial which does not contain unconfounded information on anthracycline cardiotoxicity; difference in chemotherapy other than anthracyclines between intervention and control group.
Kilickap 2007	No randomised controlled trial.
Kinoshita 2004	Similar anthracycline peak dosis between intervention and control group; anthracycline infusion duration not mentioned; difference in cumulative anthracycline dosis between intervention and control group.
Krupicka 2002	Difference in cumulative anthracycline dosis between intervention and control group.
Lalisang 1997	Difference in cumulative anthracycline dosis between intervention and control group; dose‐finding study.
Levitt 2004	No randomised controlled trial.
Lippens 1987	No randomised controlled trial.
Luck (study A) 1997	No randomised controlled trial; duplicate publication of Luck (study B) 1997.
Luck (study B) 1997	No randomised controlled trial; duplicate publication of Luck (study A) 1997.
Magné 2009	No randomised controlled trial.
Marschner 1994	Difference in cumulative anthracycline dosis between intervention and control group.
Miller 1999	Heart failure not mentioned.
Moebus 2010	Difference in cumulative anthracycline dosis between intervention and control group.
Nemoto 1987	Similar anthracycline peak dosis and infusion duration between intervention and control group.
Nielsen 1998	Similar anthracycline peak dosis and infusion duration between intervention and control group. Only a part of the patients received the same cumulative anthracycline dosis and no separate results were given for these patients; the investigators were not able to provide this information.
Nuzzo 2011	Difference in cumulative anthracycline dosis between intervention and control group.
O'Bryan 1977	Difference in planned cumulative anthracycline dosis between intervention and control group.
Ohmachi 2011	Difference in therapy other than anthracyclines between intervention and control group; similar anthracycline peak dosis between intervention and control group; anthracycline infusion duration not mentioned.
Rubin 1980	Difference in chemotherapy other than anthracyclines between intervention and control group.
Stapleton 2007	No randomised controlled trial.
Sutton 1989	Difference in chemotherapy other than anthracyclines between intervention and control group; duplicate publication of Ehrlich 1979.
Swain 2003	No randomised controlled trial.
SWOG S0221	Difference in chemotherapy other than anthracyclines between intervention and control group; ongoing study.
Torti 1983	No randomised controlled trial.
Umsawasdi 1989	Difference in both anthracycline peak dosis and infusion duration between intervention and control group.
Valdivieso 1984	Number of patients with abnormal cardiac function not mentioned.
Watanabe 2011	Difference in therapy other than anthracyclines between intervention and control group; similar anthracycline peak dosis between intervention and control group; anthracycline infusion duration not mentioned.
Wood 1994	Cumulative anthracycline dosis of intervention and control group not mentioned.
Woodward 2003	No randomised controlled trial.
Yates 1982	Difference in cumulative anthracycline dosis between intervention and control group.