Comparison 1. Pregabalin versus placebo (studies of classic design).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At least 30% pain relief	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [0.78, 1.65]
1.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [1.20, 1.62]
1.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [1.31, 1.68]
1.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [1.17, 1.63]
2 At least 50% pain relief	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.53, 1.86]
2.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.51 [1.20, 1.90]
2.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	1.75 [1.44, 2.13]
2.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [1.28, 2.10]
3 Much or very much improved	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.84, 1.80]
3.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [1.14, 1.56]
3.3 Pregabalin 450 mg daily	5	1869	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [1.16, 1.52]
3.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [1.25, 1.75]
4 Very much improved	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.59 [1.22, 2.08]
4.2 Pregabalin 450 mg daily	5	1869	Risk Ratio (M‐H, Fixed, 95% CI)	1.86 [1.47, 2.35]
4.3 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [1.13, 2.38]
5 All‐cause withdrawal	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.55, 1.30]
5.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.90, 1.25]
5.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.92, 1.24]
5.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	1.34 [1.13, 1.58]
6 Adverse event withdrawal	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.48, 2.48]
6.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.58 [1.20, 2.08]
6.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	2.04 [1.59, 2.62]
6.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	2.54 [1.94, 3.32]
7 Lack of efficacy withdrawal	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.33, 1.32]
7.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	0.43 [0.28, 0.65]
7.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.24, 0.52]
7.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	0.28 [0.15, 0.50]
8 Participants with at least one adverse event	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.89, 1.15]
8.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [1.09, 1.21]
8.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [1.18, 1.29]
8.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [1.17, 1.31]
9 Participants with at least one serious adverse event	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
9.1 Pregabalin 300 mg daily	2	735	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.19, 2.35]
9.2 Pregabalin 450 mg daily	3	1238	Risk Ratio (M‐H, Fixed, 95% CI)	1.85 [0.75, 4.60]
9.3 Pregabalin 600 mg daily	2	742	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.32, 3.03]
10 Participants experiencing somnolence	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
10.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	3.47 [1.45, 8.33]
10.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	4.01 [2.80, 5.76]
10.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	3.26 [2.59, 4.10]
10.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	4.53 [3.06, 6.70]
11 Participants experiencing dizziness	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
11.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	2.13 [1.18, 3.82]
11.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	3.08 [2.41, 3.93]
11.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	4.22 [3.40, 5.23]
11.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	4.44 [3.42, 5.75]
12 Participants experiencing weight gain	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
12.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	4.96 [1.11, 22.21]
12.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	4.64 [2.73, 7.89]
12.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	4.47 [2.93, 6.83]
12.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	5.37 [3.07, 9.38]
13 Participants experiencing peripheral oedema	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
13.1 Pregabalin 150 mg daily	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	6.95 [0.87, 55.68]
13.2 Pregabalin 300 mg daily	4	1375	Risk Ratio (M‐H, Fixed, 95% CI)	3.01 [1.69, 5.33]
13.3 Pregabalin 450 mg daily	5	1874	Risk Ratio (M‐H, Fixed, 95% CI)	3.49 [2.08, 5.84]
13.4 Pregabalin 600 mg daily	3	1122	Risk Ratio (M‐H, Fixed, 95% CI)	4.23 [2.40, 7.46]