Study	Reason for exclusion
Geng 2011	A retrospective study evaluating characteristics and outcomes for 23 women with high‐risk HM who received prophylactic chemotherapy (5‐FU or dactinomycin)
Uberti 2006	A retrospective study evaluating a bolus dose of dactinomycin for prevention of persistent GTD in 29 adolescents with high‐risk molar pregnancy compared with a similar control group of 31 adolescents
Uberti 2009	A retrospective study evaluating the effect of a bolus dose of dactinomycin, given 1 hour before ERPC to women with high‐risk HM, on the rate of malignant transformation to GTN

5‐FU: 5‐fluorouracil; ERPC: evacuation of retained products of conception; GTD: gestational trophoblastic disease; GTN: gestational trophoblastic neoplasia; HM: hydatidiform mole.