Summary of findings 3. Sugar versus placebo for infantile colic.

Sugar versus placebo for infantile colic
Patient or population: infants with infantile colic Settings: university hospital (Turkey) Intervention: sugar versus placebo
Outcomes	Illustrative comparative risks* (95% CI)		Relative effect (95% CI)	No. of participants (studies)	Quality of the evidence (GRADE)	Comments
	Assumed risk	Corresponding risk
	Control	Sugar vs placebo
Reduction in crying duration Difference before and after treatment (hours per day of crying) Follow‐up: mean 7 days	Mean reduction in crying duration in control groups was 0.09 hours/d of crying.	Mean reduction in crying duration in intervention groups was 1.72 higher (1.38 to 2.06 higher).	MD 1.72 (1.38 to 2.06)	70 (1 study)	⊕⊝⊝⊝ Very lowa,b	‐
*The basis for the assumed risk (e.g. median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; GRADE: Grades of Recommendation, Assessment, Development and Evaluation; MD: mean difference.
GRADE Working Group grades of evidence. High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

^aHigh risk of selection, performance, detection, reporting and other bias.
 ^bOnly one study with 70 infants.