3. Results for adverse events.

Study	Experimental treatment	Control	Number of participants analysed (treatment/control)	Number of adverse events in treatment arm	Types of adverse events in treatment arm (number)	Number of adverse events in control arm	Types of adverse events in control arm (number)	Notes
Akçam 2006	Glucose (30%)	Placebo	25/25	0	‐	0	‐	No adverse effect
Alexandrovich 2003	Fennel (oil emulsion)	Placebo	62/59	0	‐	0	‐	No adverse effect
Alves 2012	Simethicone	Mentha	30/30	0	‐	0	‐	No adverse effect
Arikan 2008	Sucrose (12%) or herbal tea (fennel)	No treatment	35/35/35	UK	‐	UK	‐	‐
Blomquist 1983	Dicyclomine plus sugar	Placebo	18/18	UK	‐	UK	‐	‐
Danielsson 1985	Simethicone	Placebo	27/27	UK	‐	UK	‐	‐
Gomirato 1989	Cimetropium bromide 2.0 mg/kg	Cimetropium bromide 1.2 mg/kg	20/20	4	Constipation (4)	0	‐	‐
Grunseit 1977	Dicyclomine	Placebo	22/22	3	1	Constipation (2), loose motions (1)	Constipation (1)	‐
Hwang 1985	Dicyclomine	Placebo	30/30	4	Drowsy (4)	1	Drowsy (1)	‐
Illingworth 1959	Dicyclomine	Placebo	16/16	UK	‐	UK	‐	‐
Markestad 1997	Sucrose (12%)	Placebo	19/19	UK	‐	UK	‐	‐
Metcalf 1994	Simethicone	Placebo	83/83	UK	‐	UK	‐	‐
Montaseri 2013	Fumaria extract	Placebo	26/24	UK	‐	UK	‐	‐
Savino 2002	Cimetropium bromide	Placebo	43/43	23	Meteorism (8); vomiting (1); sleepiness (7); inappetence (1); cutaneous reactions (3); constipation (3)	19	Meteorism (12); sleepiness (1); restlessness (1); constipation (5)	‐
Savino 2005	Herbal tea (chamomile/fennel/balm‐mint)	Placebo	41/47	16	Vomiting (8); sleepiness (2); inappetence (1); cutaneous reactions (1); constipation (4)	12	Vomiting (2); sleepiness (1); restlessness (1); inappetence (3); constipation (5)	‐
Sethi 1988	Simethicone	Placebo	26/26	0	‐	0	‐	No adverse effect
Weissbluth 1984	Dicyclomine	Placebo	24/24	2	Longer sleep (1); wide‐eyed (1)	0	‐	‐
Weizman 1993	Herbal tea (chamomile/vervain/licorices/fennel/balm‐mint)	Placebo	33/35	UK	‐	UK	‐	‐

UK: unknown.