Mock 2004.

Methods	RCT, 2 groups Study start and stop dates: Potential participants were identified between 1998 and 2001 Length of intervention: 6 weeks to 6 months, depending on the duration of the adjuvant therapy Length of follow‐up: end of intervention
Participants	119 breast cancer patients, stages 0 to III, after surgery, receiving chemotherapy or radiotherapy, sedentary
Interventions	Intervention (n = 60): aerobic training (walking), self directed, 50% to 70% HRmax, 15 min per session, increased to 30 min as training progressed, 5 to 6/x week. Radiotherapy: 6 weeks exercise; chemotherapy: 3 to 6 months exercise. Control (n = 59): usual care
Outcomes	fatigue: PFS physical performance: 12‐minute walk test physical activity: Physical Activity Questionnaire (PAQ) symptoms: Symptom Assessment Scales Outcomes measured at: baseline and end of the adjuvant therapy/intervention
Notes	Funding: FIRE (Fatigue Initiative in Research and Education) multi‐institutional award from the Oncology Nursing Society Foundation Conflict of interest: Not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomisation
Allocation concealment (selection bias)	Low risk	Consecutively numbered, sealed, opaque envelopes, opened after baseline testing
Blinding of participants All outcomes	High risk	Not done
Blinding of personnel/care providers All outcomes	High risk	Not reported Comment: probably not done
Blinding of outcome assessment (detection bias) Fitness outcomes	High risk	Not reported Comment: probably not done
Blinding of outcome assessment (detection bias) All outcomes except fitness outcomes	High risk	Self reported items
Incomplete outcome data (attrition bias) All outcomes	Low risk	Drop‐out: Intervention group: 6/60 (10%) Control group: 5/59 (8.5%) All participants 11/119 (9.2%) Reported both ITT and per‐protocol analysis
Selective reporting (reporting bias)	Unclear risk	No study protocol published
Group similarity at baseline	Low risk	No significant differences
Adherence	High risk	Not adherent: 15/54 (28%). 72% were adherent in the sense of the studies' definition (85% of minimum prescription)
Contamination	High risk	Contamination: 21/54 (39%) of the control group were exercising