Winningham 1988.

Methods	RCT, 3 groups Study start and stop dates: not reported Length of intervention: 10 weeks Length of follow‐up: end of intervention
Participants	42 breast cancer patients, after surgery, receiving chemotherapy, within the first 6 months of chemotherapy, but having had at least 3 treatments prior to entering the study program, not on doxorubicin, Karnofsky 60% to 100%. None of the participants received antiemetic medication
Interventions	Intervention (n = 16): aerobic training (cycling, interval training), 60% to 85% HRmax, 20 to 30 min per session, 3/week, 10 weeks, supervised Control group 1 (n = 12): no intervention Control group 2 (n = 14): "placebo" mild stretching, conversation, 1/week, supervised
Outcomes	Nausea: Symptom Checklist 90 Revised (SCL‐90‐R) Somatisation: SCL‐90‐R Outcomes measured at baseline and end of intervention
Notes	Funding: Not reported Conflict of interest: Not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Stated as randomised. The generation of the random sequence was not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants All outcomes	High risk	Placebo group Comment: Patients in the placebo group would have been aware that they were not in the exercise group, but in the stretching group
Blinding of personnel/care providers All outcomes	High risk	Not reported. Comment: probably not done
Blinding of outcome assessment (detection bias) All outcomes except fitness outcomes	High risk	Self reported items
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were accounted for
Selective reporting (reporting bias)	High risk	Participants answered all 90 items of the SCL‐90‐R. Hereby, "the investigators hoped to avoid sensitizing patients to awareness of any one symptom". Results for other items apart from nausea and somatisation part were not reported
Group similarity at baseline	High risk	"similar in age, height and body weight". Participants in control group were higher educated than those in exercise and placebo groups. Placebo group had more married women than exercise and placebo groups.
Adherence	Unclear risk	Not reported
Contamination	Unclear risk	Contamination not reported. Inclusion criterion: "not in an exercise program". Control participants were advised to notify project personnel if they began exercising on a regular basis either as part of a group or on their own