1. Sensitivity analysis: random‐effects versus fixed‐effect models.

Analysis	Random‐effects model	Fixed‐effect model
People with 1 or more exacerbations requiring systemic corticosteroids (risk difference)	(RD ‐0.01, 95% CI ‐0.04 to 0.02)	(RD ‐0.03, 95% CI ‐0.07 to 0.01)
ACT/C‐ACT score	(MD ‐0.08, 95% CI ‐0.70 to 0.54)	(MD ‐0.09, 95% CI ‐0.64 to 0.46)
People with 1 or more serious adverse event due to any cause	(OR 1.01, 95% CI 0.54 to 1.89)	(OR 1.00, 95% CI 0.54 to 1.85)
People with 1 or more study‐defined exacerbation	(OR 0.53, 95% CI 0.28 to 0.99)	(OR 0.66, 95% CI 0.48 to 0.91)
% eosinophils, lower airway	(MD ‐0.38, 95% CI ‐1.92 to 1.15)	(MD ‐0.26, 95% CI ‐1.35 to 0.83)
Peak expiratory flow rate	(MD 3.16, 95% CI ‐13.40 to 19.72)	(MD 4.09, 95% CI ‐1.34 to 9.52)
People withdrawing from the trial	(OR 1.07, 95% CI 0.73 to 1.58)	(OR 1.09, 95% CI 0.74 to 1.59)

Sensitivity analyses are presented only for those outcomes where results of analyses using random‐effects versus fixed‐effect models are non‐identical.

Abbreviations: CI, confidence interval; MD, mean difference; OR, odds ratio; RD, risk difference.