Study	Reason for exclusion
Alansari 2015	Not placebo controlled
Arshi 2014	Not placebo controlled
Bantz 2015	Single‐blind study
Bar Yoseph 2015	Duration < 12 weeks
Baris 2014	Not placebo controlled
Breitenbuecher 2012	Duration < 12 weeks
Darabi 2013	Not placebo controlled
De Groot 2015	Duration < 12 weeks
Goldring 2013	Primary prevention study
Lakatos 2000	Bone outcomes only
Litonjua 2014	Primary prevention study, protocol only
McDonald 2006	Bone outcomes only
Menon 2014	Not placebo controlled
Nanzer 2014	Duration < 12 weeks
Price 2015	Duration < 12 weeks
Rajanandh 2015	Not placebo controlled
Schou 2003	Duration < 12 weeks
Thijs 2011	Duration < 12 weeks
Torres 2013	Duration < 12 weeks
Utz 1976	Duration < 12 weeks
Worth 1994	Bone outcomes only
Yemelyanov 2001	Bone outcomes only