Comparison 11.

Adverse events

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death through radiation tissue injury	2	633	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [0.89, 3.03]
2 Severe radiation tissue injury	7	779	Risk Ratio (M‐H, Fixed, 95% CI)	2.35 [1.66, 3.33]
3 Severe radiation tissue injury ‐ best case scenario	7	803	Risk Ratio (M‐H, Fixed, 95% CI)	1.94 [1.39, 2.69]
4 Severe radiation tissue injury ‐ worst case scenario	7	803	Risk Ratio (M‐H, Fixed, 95% CI)	2.69 [1.92, 3.77]
5 Acute central nervous system oxygen toxicity	4	331	Risk Ratio (M‐H, Fixed, 95% CI)	6.76 [1.16, 39.31]
5.1 12 or fewer oxygen fractions	3	242	Risk Ratio (M‐H, Fixed, 95% CI)	4.30 [0.47, 39.60]
5.2 More than 12 oxygen fractions	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	10.76 [0.61, 188.98]
6 Acute central nervous system toxicity ‐ best case scenario	4	337	Risk Ratio (M‐H, Fixed, 95% CI)	3.00 [0.81, 11.10]
6.1 12 or fewer oxygen fractions	3	248	Risk Ratio (M‐H, Fixed, 95% CI)	1.30 [0.26, 6.53]
6.2 More than 12 oxygen fractions	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	10.76 [0.61, 188.98]
7 Acute central nervous system toxicity ‐ worst case scenario	4	337	Risk Ratio (M‐H, Fixed, 95% CI)	9.74 [1.73, 54.98]
7.1 12 or fewer oxygen fractions	3	248	Risk Ratio (M‐H, Fixed, 95% CI)	9.12 [1.05, 79.50]
7.2 More than 12 oxygen fractions	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	10.76 [0.61, 188.98]
8 Middle ear barotrauma	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	6.85 [0.36, 128.83]