Brady 1981

Methods	RCT with allocation concealment not clear, method of randomisation not stated. Patient, outcome assessors and treating team all aware of allocation. No indication of power calculation
Participants	65 adults with Stage IIb to IVa carcinoma of the uterine cervix where radiotherapy was the treatment of choice. 34 allocated to HBOT and 31 to control. Several participants refused HBOT and there were only 19 of 34 available for analysis in HBOT group and 29 of 31 in the control group
Interventions	Control: 5000 rads by external beam in 25 fractions over five weeks plus radium implants where possible HBOT: 4000 rads in 10 fractions over five weeks with intracavitary implants where possible. All external beam radiotherapy conducted at 3 ATA breathing 100% oxygen, total compression time about 40 minutes
Outcomes	Death at 4 years, local recurrence at 4 years, metastases at 4 years, late radiation tissue injuries
Notes	Trial stopped due to poor accrual Schulz rating: randomisation: C; allocation concealment: B; selection bias: C; blinding: C
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear