Quasha 1980.

Methods	Parallel‐group randomized controlled trial, conducted in the United States. Study dates not reported
Participants	38 elective coronary artery bypass graft patients with normal and slightly impaired left ventricular function
Interventions	Early extubation within 8 hours of surgery in 18 participants Usual care: extubation applied in the morning of the first day after surgery in 20 participants Details of weaning protocol and who decided when to extubate were not given.
Outcomes	Risk of tracheal reintubation Risk of postoperative myocardial infarction (increase in myocardial enzyme values, positive technetium pyrophosphate scan and meeting predefined electrocardiographic criteria) Risk of major bleeding (necessitating surgical control) Risk of stroke Time to extubation Length of stay in the ICU
Notes	Inhalation‐based anaesthesia was the same in both groups, but weaning criteria were applied earlier in the early extubation group. No power calculation was done. Study was supported, in part, by UPHS Grant (grant number: GMS‐15571‐10,11). Details of any declarations of conflict of interest among study authors were not provided.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details given
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding (performance bias and detection bias) All outcomes	Low risk	Assessors for diagnosis of myocardial infarction were blinded to group allocation.
Incomplete outcome data (attrition bias) All outcomes	High risk	Two participants failed to meet the early extubation criteria and were excluded from data analysis on time to extubation.
Selective reporting (reporting bias)	Low risk	Reported all outcomes collected
Other bias	Low risk	Baseline characteristics were similar for age, weight, gender, preoperative ventricular function and preoperative pulmonary function.