Naik 2006.

Methods	RCT, single centre 13 women randomised
Participants	Age: mean 44.6 years, range: 26 to 63 VIN grade: all 13 high‐grade Smoking: smokers (n = 9), non‐smokers (n = 3) HPV status: not documented Recurrent disease: not reported Focality: unifocal (n = 9), multifocal (n = 3)
Interventions	Oral indole‐3‐carbinol: 200 mg/day versus 400 mg/day for 6 months
Outcomes	Response to treatment: 6 weeks, 12 weeks and 6 months Urine: 2‐hydroxyestrone:16‐alpha‐hydroxyestrone ratio Symptom improvement Side effects
Notes	Vitamin C was commenced at the discretion of the investigator
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	High risk	% analysed: 10/13 (77%) "One patient was withdrawn from the study at the 6‐week visit as there was difficulty in obtaining the I3C and two women did not attend the 6‐month review."
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists
Overall risk	High risk	Insufficient information