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. 2014 May 15;2014(5):CD010681. doi: 10.1002/14651858.CD010681.pub2

Summary of findings 2. Summary of findings.

Adjuvant cisplatin/doxorubicin/paclitaxel (CDP) compared with cisplatin/doxorubicin (CD) for women with advanced (stage III/IV) endometrial cancer
Patient or population: women with advanced (stage III/IV) endometrial cancer after surgery and radiotherapy
Settings: hospital
Intervention: CDP
Comparison: CD
Outcomes Relative effect
(95% CI) No of participants
(trials) Quality of the evidence
(GRADE) Comments
PFS (stage III/IV)
Median follow‐up 46/47 months
HR 0.90 (0.69 to 1.17) 552
(1) ⊕⊕⊕⊝
moderate We considered this evidence high quality but downgraded it to moderate, as mature OS data has not yet been published, therefore we cannot exclude other differences in survival risks/benefits.
CI: Confidence interval; HR: Hazard ratio; PFS: Progression‐free survival; CDP: cisplatin/doxorubicin/paclitaxel; CD: cisplatin/doxorubicin.
GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.