Comparison 1. Chemotherapy vs radiotherapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 OS (Stage III/IV)	2		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
1.1.1 Stage III	2	514	Hazard Ratio (IV, Random, 95% CI)	0.76 [0.57, 1.02]
1.1.2 Stage IV	1	106	Hazard Ratio (IV, Random, 95% CI)	0.68 [0.44, 1.04]
1.1.3 Stage III/IV	2	620	Hazard Ratio (IV, Random, 95% CI)	0.75 [0.57, 0.99]
1.2 OS (stage III/IV) (unadjusted data)	2		Hazard Ratio (IV, Random, 95% CI)	0.75 [0.60, 0.94]
1.3 OS (stage III/IV dichotomous)	2	620	Risk Ratio (M‐H, Random, 95% CI)	0.79 [0.68, 0.93]
1.4 OS (Stage III only)	2		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
1.4.1 Stage IIIA	2	234	Hazard Ratio (IV, Random, 95% CI)	0.61 [0.38, 0.98]
1.4.2 Stage IIIC	2	265	Hazard Ratio (IV, Random, 95% CI)	0.76 [0.53, 1.09]
1.5 OS (Stage III dichotomous)	2	514	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.62, 0.93]
1.6 PFS (Stage III/IV)	2		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
1.6.1 Stage III	2	514	Hazard Ratio (IV, Random, 95% CI)	0.81 [0.63, 1.05]
1.6.2 Stage IV	1	106	Hazard Ratio (IV, Random, 95% CI)	0.57 [0.38, 0.86]
1.6.3 Stage III/IV	2	620	Hazard Ratio (IV, Random, 95% CI)	0.74 [0.59, 0.92]
1.7 PFS (stage III/IV dichotomous)	2	620	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.77, 1.02]
1.8 PFS (Stage III only)	2		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
1.8.1 Stage IIIA	2	234	Hazard Ratio (IV, Random, 95% CI)	0.66 [0.43, 1.01]
1.8.2 Stage IIIC	2	265	Hazard Ratio (IV, Random, 95% CI)	0.86 [0.61, 1.21]
1.9 PFS (Stage III dichotomous)	2	514	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.70, 1.01]
1.10 Severe adverse events (G3/4)	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.1 Leukopenia	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.2 Neutropenia	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.3 Thrombocytopenia	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.4 Gastrointestinal	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.5 Neurological	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.6 Infection	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.7 Skin	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.8 Genitourinary	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.10.9 Alopecia	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.11 Treatment discontinuation due to toxicity	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.12 Treatment‐related deaths	2	620	Risk Ratio (M‐H, Random, 95% CI)	1.67 [0.55, 5.00]