Placido 2004.

Study characteristics
Methods	RCT
Participants	273 women with epithelial ovarian cancer achieved CCR or partial clinical remission Stage 1c, 2, 3 and 4 Mean age was 55 years old in maintenance chemotherapy group and 56 in observation group Median follow‐up time was 28 months
Interventions	Topotecan versus observation; toxic events
Outcomes	1‐year PFS
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "…by means of a computer‐driven minimization procedure" Comment: Probably done
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding (performance bias and detection bias) All outcomes	Low risk	No blinding, but the outcome and the outcome measurement are not likely to be influenced by lack of blinding.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	All expected outcomes were reported
Other bias	Low risk	The study appears to be free of other sources of bias