Comparison 5.

Amelioration: Donepezil versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Cognitive composite score	1	144	Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.05, 0.11]
2 Cognitive functioning (timed tasks)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Speed of processing	1	145	Mean Difference (IV, Fixed, 95% CI)	‐1.82 [‐11.49, 7.85]
2.2 Executive function	1	143	Mean Difference (IV, Fixed, 95% CI)	1.61 [‐15.98, 19.20]
2.3 Psychomotor functioning (dominant hand)	1	141	Mean Difference (IV, Fixed, 95% CI)	‐11.93 [‐21.51, ‐2.35]
2.4 Psychomotor functioning (non‐dominant hand)	1	142	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐5.21, 5.19]
3 Cognitive functioning (total score)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 Attention (Digit span (total))	1	145	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐1.12, 0.80]
3.2 Attention (Digit span (backward))	1	145	Mean Difference (IV, Fixed, 95% CI)	‐0.4 [‐1.01, 0.21]
3.3 Attention (Digit Span (forward))	1	145	Mean Difference (IV, Fixed, 95% CI)	0.06 [‐0.57, 0.69]
3.4 Verbal fluency	1	145	Mean Difference (IV, Fixed, 95% CI)	‐0.92 [‐3.19, 1.35]
3.5 Short‐term verbal memory	1	145	Mean Difference (IV, Fixed, 95% CI)	0.32 [‐0.93, 1.57]
3.6 Long‐term verbal memory (recall)	1	145	Mean Difference (IV, Fixed, 95% CI)	0.35 [‐0.36, 1.06]
3.7 Long‐term verbal memory (retention)	1	145	Mean Difference (IV, Fixed, 95% CI)	3.96 [‐4.40, 12.32]
3.8 Long‐term verbal memory (recognition)	1	145	Mean Difference (IV, Fixed, 95% CI)	0.57 [0.07, 1.07]
3.9 Long‐term verbal memory (discrimination)	1	145	Mean Difference (IV, Fixed, 95% CI)	0.94 [0.27, 1.61]
3.10 Short‐term visual memory (copy)	1	144	Mean Difference (IV, Fixed, 95% CI)	‐0.69 [‐1.63, 0.25]
3.11 Short‐term visual memory (recall)	1	144	Mean Difference (IV, Fixed, 95% CI)	‐0.50 [‐1.51, 0.51]
3.12 Long‐term visual memory (retention)	1	143	Mean Difference (IV, Fixed, 95% CI)	‐0.39 [‐1.48, 0.70]