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. 2016 Sep 13;2016(9):CD010216. doi: 10.1002/14651858.CD010216.pub3
Methods Design: Prospective cohort
Recruitment: People attending an outpatient clinic
Setting: University hospital outpatient clinic, Switzerland
Inclusion criteria: Wish to reduce tobacco use or had failed to stop smoking using varenicline, bupropion or NRT in past
Participants TOTAL N: 17
mean 23 cpd, 82% had a psychiatric illness
Interventions Offered an EC with nicotine
59% also reported using NRT or varenicline in addition to EC
Outcomes Smoking cessation and reduction by at least 30% at 12 months (self‐report)
Adverse events
No significant side effects
Notes Abstract only, hence little detail available
Not clear if EC was provided by clinic or if participants had to buy their own
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Prospective cohort
Allocation concealment (selection bias) High risk Not randomized
Blinding of participants and personnel (performance bias) All outcomes High risk No blinding
Blinding of outcome assessment (detection bias) All outcomes High risk No blinding, no biochemical validation used
Incomplete outcome data (attrition bias) All outcomes Unclear risk Numbers lost to follow‐up not reported
Selective reporting (reporting bias) Unclear risk Unable to determine prespecified outcomes