NCT02357173

Trial name or title	A trial of e‐cigarettes: natural uptake, patterns and impact of use
Methods	Randomized parallel‐assignment open‐label trial
Participants	Estimated enrolment 68 Inclusion criteria: age 18+, current smoker of at least 5 cpd for at least 1 year, at least some concern for health effects of smoking Exclude if: past 6 month use of EC ever purchase of EC recent history of cardiovascular distress (heart attack in past year; arrhythmia; uncontrolled hypertension) recent history (past 3 months) of COPD, cancer (any non‐dermatologic), or uncontrolled diabetes mellitus pregnant or breastfeeding any major current psychiatric impairment, including current alcohol/drug abuse/dependence use of non‐cigarette tobacco products (e.g. cigarillos) in the last 30 days current use of any smoking cessation medications current enrolment in a smoking cessation treatment study
Interventions	2/3 sample will be given EC (Blu) for a 3‐wk period, to use as much or as little as they would like 1/3 sample will not receive EC to sample and will continue smoking their regular cigarettes as much or as little as they would like
Outcomes	At 3 months: Primary: EC uptake and use, nicotine and cotinine, antecedents of EC use, use within smoking‐restricted areas Secondary: smoking abstinence, smoking reduction, quit attempts
Starting date	November 2014
Contact information	Matthew Carpenter, Medical University of South Carolina
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