Suprasert 2008.

Study characteristics
Patient sampling	Design: Retrospective review Setting: Thailand Accrual dates: Jan 2001 to Dec 2005 No participants: 127 No assessed: 112 Inclusion criteria: Women with pelvic masses. Excluded infarcted masses (4) or deferred (18) frozen section analysis. Included previous histological diagnosis: no
Patient characteristics and setting	Pelvic masses. Thailand.
Index tests	FS. Number of frozen sections determined by attending Pathologist. Deferred FS when suspicion of borderline or malignant considered not definitely diagnostic.
Target condition and reference standard(s)	Malignant or borderline on PS.
Flow and timing	Specimens submitted to FS at surgeon's discretion ‐ no clear protocol. FS before PS.
Comparative
Notes	Retrospective review. 15 excluded due to infarction and deferred FS No stage given.Variable sections were performed by Pathologist.
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	No
Was the sample representative of patients in practice (90% stage I/II with RMI>200)?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test All tests
Were the index tests interpreted without knowledge of the reference standard?	Yes
Were the index tests Interpreted by consultant or specialist gyn‐onc pathologist?	Unclear
		Unclear	Unclear
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Did all patients receive a reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were un‐interpretable/intermediate test results reported?	Yes
Were withdrawals from the study explained?	Yes
		Low