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. 2012 Sep 12;2012(9):CD006121. doi: 10.1002/14651858.CD006121.pub3

Chougule 2000

Methods Single institution, RCT
Participants Patients with MRI confirmed 1 to 3 brain metastases, tumor volume < 30 cc and minimum of 3‐month life expectancy
Interventions WBRT alone: 31 patients received 30 Gy in 10 fractions
WBRT plus SRS: 37 patients, 30 Gy WBRT in 10 fractions plus GK SRS 20 Gy to the tumor margin
Outcomes Primary outcome: median OS
Secondary outcome: local control
Notes Abstract form only. No difference in median OS was reported in the WBRT only and WBRT plus SRS groups. Local control was reported as being superior in the WBRT plus SRS group (91%) versus 62% in the WBRT‐only group. No other outcomes were evaluated in this trial. The abstract only reported median survival and local control in the different groups without providing P values or Kaplan‐Meier analysis
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Insufficient information to permit judgment
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgment
Blinding (performance bias and detection bias) All outcomes Unclear risk Insufficient information to permit judgment
Incomplete outcome data (attrition bias) All outcomes Unclear risk Insufficient information to permit judgment
Selective reporting (reporting bias) Unclear risk Insufficient information to permit judgment
Other bias Unclear risk Insufficient information to assess whether an important risk of bias exists