Chougule 2000

Methods	Single institution, RCT
Participants	Patients with MRI confirmed 1 to 3 brain metastases, tumor volume < 30 cc and minimum of 3‐month life expectancy
Interventions	WBRT alone: 31 patients received 30 Gy in 10 fractions WBRT plus SRS: 37 patients, 30 Gy WBRT in 10 fractions plus GK SRS 20 Gy to the tumor margin
Outcomes	Primary outcome: median OS Secondary outcome: local control
Notes	Abstract form only. No difference in median OS was reported in the WBRT only and WBRT plus SRS groups. Local control was reported as being superior in the WBRT plus SRS group (91%) versus 62% in the WBRT‐only group. No other outcomes were evaluated in this trial. The abstract only reported median survival and local control in the different groups without providing P values or Kaplan‐Meier analysis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgment
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgment
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Insufficient information to permit judgment
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgment
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgment
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists