Cai 2007.
Methods | RCT Setting: China Funding: departmental |
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Participants | 62 ASA 1 to 2 patients, aged 33 to ˜60 years, weighing 42 to ˜56 kg, scheduled for elective gastrectomy Exclusion criteria were abnormal heart, lung, liver, kidney and coagulation function and history of recent use of hormone or non‐steroidal anti‐inflammatory drugs |
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Interventions |
Treatment groups: thoracic epidural analgesia (T7‐T8; catheter advanced 3 to 4 cm passed the needle tip, test dose 3 mL of 1% lidocaine) with ropivacaine 0.25% (for sensory level to T4) and morphine 2 mg (before surgical incision), combined with postoperative epidural analgesia with ropivacaine 0.15% and morphine 1.5 mcg/mL at 2 mL/h for 72 hours (n = 22) or ropivacaine 0.25% 10 mL and morphine 2 mg (before surgical incision, postoperative epidural analgesia with ropivacaine 0.15% and morphine 1.5 mcg/mL at 2 mL/h for 72 hours (n = 22) Control group: postoperative intravenous analgesia with fentanyl 0.1 mg IV at the end of surgery, followed by continuous intravenous fentanyl 0.25 mcg//mL and droperidol 0.05 mg/mL at a rate of 2 mL/h for 72 hours (n = 22) General anaesthesia with propofol, fentanyl isoflurane and vecuronium for all participants |
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Outcomes | Pain scores at rest and on coughing (taken as on movement) at 8, 12, 24, 48 and 72 hours after surgery | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "randomly divided", no details |
Allocation concealment (selection bias) | Unclear risk | Not mentioned |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not mentioned |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not mentioned |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No loss to follow‐up mentioned |
Selective reporting (reporting bias) | Low risk | All results reported |
Other bias | Low risk | Groups well balanced |