Malenkovic 2003.
Methods | RCT Setting: Serbia Funding: unspecified |
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Participants | 67 ASA 1 to 5 patients undergoing laparotomy for various surgeries | |
Interventions |
Treatment group: combined spinal (4.5 mg of 0.25% bupivacaine plus 0.2 mg of morphine) lumbar (L1‐L2 or L2‐L3; catheter tested with 3 mL of 2% lidocaine) epidural analgesia loaded with 10 mL of 0.25% bupivacaine followed by 3 to 5 mL of 0.25% bupivacaine every hour during surgery and bupivacaine 0.125% to 0.25% 15 mL every 8 to 12 hours started on postoperative day 2 and kept for 2 or 3 days (n = 34) Control group: acetaminophen and butorphanol (n = 33) General anaesthesia for all participants |
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Outcomes | Intestinal motility: "faster for epidural group" Pain at rest and on movement Length of hospital stay |
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Notes | Pain scores, intestinal motility and length of hospital stay measured but results not provided; no corresponding address for postal mail and invalid email address given | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "randomized", no details |
Allocation concealment (selection bias) | Unclear risk | Not mentioned |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | "double‐blind", no sham block |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | "double‐blind" |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No loss to follow‐up |
Selective reporting (reporting bias) | Unclear risk | Results not provided |
Other bias | High risk | Participants of the epidural group also had spinal anaesthesia with bupivacaine and morphine. This is different from the other studies |