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. 2016 Jul 15;2016(7):CD001893. doi: 10.1002/14651858.CD001893.pub2

Rutberg 1984.

Methods RCT
Approved by the ethics committee and informed consent obtained
Setting: Sweden
Funding: governmental (plus a contribution from the industry)
Participants 24 female patients undergoing cholecystectomy
Interventions Treatment group: TEA (T9‐T10 or T10‐T11) with bupivacaine 0.5% before surgery and 0.25% to 0.375%, 5 to 8 mL to maintain segmental blockade from T4 to L3 (n = 8) for 24 hours
 Control group: epidural morphine 4 mg in 7 mL of saline, repeated every 10 hours (n = 8), and postoperative IV morphine 2.5 mg as required (n = 8)
General anaesthesia for all participants
Outcomes VAS scores at 6 and 24 hours (not clearly mentioned, taken as at rest)
Notes Study includes a third group referred to as "control" group and not retained for the purpose of this meta‐analysis
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "randomly allocated", no details
Allocation concealment (selection bias) Unclear risk Not mentioned
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Not mentioned
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not mentioned
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up and no epidural failure mentioned
Selective reporting (reporting bias) Low risk All results provided
Other bias Low risk Groups well balanced