7. Trials assessing pain during bladder catheterization.

Study	Participants	Procedures	Intervention	Outcomes	Metrics used	Results
Rogers 2006	83 infants ≤ 90 days of age requiring bladder catheterization. 3 infants were withdrawn after randomisation as a result of inappropriate enrolment or withdrawal of consent Subgroup analysis performed: infants 1 to 30, 31 to 60 and 61 to 90 days of age	Bladder catheterization	2 min before procedure: 2 mL sterile water via syringe (n = 40) 2 mL 24% sucrose (0.48 g) via syringe (n = 40)	% of subjects crying at maximal insertion Change in DAN scores	Change in mean (SD) for DAN score	Subgroup analysis of youngest infants (1 to 30 days) in sucrose group showed smaller changes in DAN score compared to water group (2.86 vs. 5.29; P = 0.035) Subgroup analysis of infants (1 to 30 days) showed infants in sucrose group were significantly less likely to cry during maximal catheter insertion compared to water group (28.6% vs. 78.6%; P = 0.008) Change in DAN score and number of infants crying at maximal catheter insertion used in meta‐analysis

Abbreviations

DAN = Douleur Aiguë du Nouveau‐né Scale
 SD = standard deviation