Garin 1988

Methods	Study design: cross‐over RCT Time frame: not reported Follow‐up period: 3 months
Participants	Setting: tertiary centre Country: USA SRNS defined as proteinuria 40 mg/m2/h, or > 50 mg/kg/d and serum albumin < 25 g/L after 8 weeks of prednisone (2 mg/kg/d); not reported whether children had initial or delayed steroid resistance Number: 8 Age: 3 to 18 years Sex (M/F): 6/2 Histology: MCD (4); FSGS (4) Exclusion criteria: not reported
Interventions	CSA group 5 mg/kg/d for 8 weeks adjusted to level ≤ 200 ng/mL No treatment group No treatment for 8 weeks Co‐interventions Not reported; no patient on prednisone during study
Outcomes	Complete remission at 8 weeks: not defined Partial remission at 8 weeks: not defined
Notes	Exclusions post randomisation but pre‐intervention: none reported Stop or end points/s: not reported Additional data requested from authors: none
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	High risk	Participants/investigators not blinded; lack of blinding could influence management
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Primary outcome was laboratory outcome based and unlikely to be influenced by lack of blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients followed up and accounted for
Selective reporting (reporting bias)	Low risk	Complete/partial remission/adverse effects reported
Other bias	Unclear risk	Funding source not reported