Kleinknecht 1980

Methods	Study design: parallel RCT Time frame: not reported Follow‐up period: greater than 6 months
Participants	Setting: tertiary centre Country: France Children with SRNS (persistent nephrotic syndrome after 5 weeks or more of prednisone at 2 mg/kg/d); not stated whether children had initial or delayed steroid resistance Number (chlorambucil/indomethacin): 15/15 Age: not reported Sex (M/F): not reported Histology Chlorambucil group: MCD (5); FSGS (6); FSGS with mesangial proliferation (4) Indomethacin group: MCD (4); FSGS (8); FSGS with mesangial proliferation (2) Exclusion criteria: steroid responsive not reported
Interventions	Chlorambucil group 0.2 mg/kg/d for 6 months Indomethacin group 3 mg/kg/d for 6 months Co‐interventions: not reported
Outcomes	Remission of nephrotic syndrome: definition not reported after at least 6 months ESKD
Notes	Exclusions post randomisation but pre‐intervention: not reported Stop or end points/s: not reported Additional data requested from authors: none
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	High risk	No blinding of investigators/participants; lack of blinding could influence management.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information about how primary outcome was measured
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Data only available from conference proceedings
Selective reporting (reporting bias)	Unclear risk	Complete remission (no definition provided), ESKD
Other bias	Unclear risk	Funding source not stated Data from conference proceedings