. Author manuscript; available in PMC: 2019 Jul 23.

Published in final edited form as: Nature. 2019 Jan 23;565(7741):654–658. doi: 10.1038/s41586-019-0882-3

Extended Data Table 2. Results from multivariable model for overall survival from the time of CSF collection.

Analysis showed that CSF positivity was significantly associated with an increased rate of death from the time of CSF collection in an analysis also accounting for the following variables: 1) % extent of resection at diagnosis; 2) Tumor burden at the time of CSF collection; 3) IDH status. n=63 biologically independent samples were included in the analysis. This number comprises n = 33 samples from CSF ctDNA positive patients and n =30 samples from CSF ctDNA negative patients. The statistical tests used for the analysis were Wald tests and they are two-sided. HR=Hazard Ratio; CI=confidence interval.

Variable	Category	HR	95% CI	p-value
% Extent of resection at diagnosis	continuous	1.005	0.997-1.013	0.26
Tumor burden at LP/CSF	continuous	1.0002	1.0001-1.0004	0.007
CSF positivity	Negative	ref	--	--
CSF positivity	Positive	4.16	2.15-8.05	0.000024315
IDH Status	Mutant	ref	--	--
IDH Status	WT	12.01	4.44-32.49	0.0000009778250