1. Data extracted from each study.
| Study ID | First author, year of publication |
| Type of study | Journal article or conference abstract |
| Clinical features and settings | Presenting signs and symptoms |
| Clinical selection of patients (none, clinical score, explicit criteria but not a score, implicit criteria) | |
| Exclusion if antibiotics use before inclusion (yes/no) | |
| Clinical setting (office‐based, emergency department, walk‐in clinic, mixed, other) | |
| Single‐ or multi‐centre study | |
| Age range for inclusion | |
| Participants | Sample size (n) |
| Age (distribution) | |
| GAS prevalence according to culture (with 95% confidence interval) | |
| Country of study | |
| Sex (% of girls) | |
| Clinical severity assessment (Centor score, McIsaac score, other, none) | |
| Study design | Cross‐sectional study or RCT |
| Retrospective or prospective design | |
| Sample (consecutive, random or unclear) | |
| Direct comparison of different RADTs (yes/no) | |
| Direct comparison of several throat culture techniques (yes/no) | |
| Throat swab (1 single, 1 double, 2 different) | |
| Person performing the throat sample (physician, nurse, laboratory personnel, other) | |
| Reference standard(s) | Throat culture medium (standard, enrichment, inhibitory) |
| Atmosphere of incubation (aerobic, aerobic with CO2 enrichment, anaerobic) | |
| Duration of incubation (≤ 24, 24 to 48, ≥ 48 hours) | |
| GAS confirmation (bacitracin disk, latex test, other, none) | |
| Number of plates inoculated (n) | |
| Assessment of GAS antibody response (yes/no) | |
| Relevant details | |
| Index tests | Commercial name of the RADT |
| Type of RADT (EIA, OIA) | |
| Data | Number of true positives, false positives, true negatives, false negatives and undetermined/uninterpretable results |
| Notes | Source of funding (whether any of the authors is affiliated with the manufacturer of the RADT, the study was directly funded by the manufacturer, authors reported conflicts of interests related to the manufacturer or other funding sources) |
| Anything else of relevance |
RADT: rapid antigen detection test EIA: enzyme immunoassay OIA: optical immunoassay CO2: carbon dioxide