4. Results of sensitivity analyses.

Concerns	Domain	Studies at low risk (n)	Sensitivity (95% CI)	Specificity (95% CI)
Risk of bias	Patient selection	25	85.7 (82.1 to 88.6)	93.0 (91.1 to 94.5)
	Index test	65	86.6 (84.0 to 88.8)	95.2 (94.1 to 96.1)
	Reference standard	20	81.0 (74.1 to 86.5)	95.5 (93.4 to 96.9)
	Flow and timing	98	85.4 (83.0 to 87.5)	95.3 (94.4 to 96.1)
	≥ 3 domains with low risk of bias	20	84.0 (79.4 to 87.8)	95.0 (93.1 to 96.4)
Applicability
	Patient selection	41	83.1 (79.7 to 86.0)	94.9 (93.4 to 96.0)
	Index test	33	89.1 (85.7 to 91.8)	95.0 (93.2 to 96.4)
	Reference standard	60	84.9 (81.6 to 87.6)	94.7 (93.5 to 95.7)

CI: confidence interval