| Study | Reason for exclusion |
|---|---|
| Abu‐Sabaah 2006 | Not ambulatory care setting |
| Andersen 1994 | Mixed age but no paediatric data |
| Andersen 2003a | Duplicate publication |
| Andersen 2003b | Not ambulatory care setting |
| Anhalt 1992 | Mixed age but no paediatric data |
| Anonymous 1985a | Editorial, letter or review |
| Anonymous 1985b | Duplicate publication |
| Anonymous 1985c | Duplicate publication |
| Anonymous 1986 | Editorial, letter or review |
| Anonymous 1991 | Editorial, letter or review |
| Anonymous 1992 | Editorial, letter or review |
| Araj 1986 | RADT other than EIA or OIA |
| Araujo 2005 | Adults or unclear age |
| Armengol 2004a | Reference standard not laboratory culture |
| Armengol 2004b | Reference standard not laboratory culture |
| Arya 1993 | Editorial, letter or review |
| Atlas 2005 | Adults or unclear age |
| Ausina 1987 | Editorial, letter or review |
| Ba‐Saddik 2014 | RADT other than EIA or OIA |
| Badgett 1996 | Editorial, letter or review |
| Baker 1995 | Mixed age but no paediatric data |
| Baselski 1988 | Adults or unclear age |
| Berger‐Jekic 1987 | RADT other than EIA or OIA |
| Berke 1989 | Editorial, letter or review |
| Betriu 1988 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Betriu 1989 | Adults or unclear age |
| Bischoff 2007 | Editorial, letter or review |
| Bjerrum 2013 | Editorial, letter or review |
| Blade 1991 | Mixed age but no paediatric data |
| Blanco 1988 | Duplicate publication |
| Boccazzi 2011 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Bodino 1987 | RADT other than EIA or OIA |
| Boss 1992 | Editorial, letter or review |
| Bourbeau 1993 | Mixed age but no paediatric data |
| Brahmadathan 1986 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Burke 1988 | Mixed age but no paediatric data |
| Calvino 2015 | Adults or unclear age |
| Cardoso 2013 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Carey 1991 | Mixed age but no paediatric data |
| Centor 1984 | RADT other than EIA or OIA |
| Centor 1985 | RADT other than EIA or OIA |
| Chen 2000 | Editorial, letter or review |
| Chessman 1998 | Editorial, letter or review |
| Choi 1995 | Adults or unclear age |
| Coban 2013 | Not ambulatory care setting |
| Cohen 1993 | Editorial, letter or review |
| Cohen 2000 | Editorial, letter or review |
| Cohen 2012a | Duplicate publication |
| Cohen 2013a | Duplicate publication |
| Corneli 2001 | Editorial, letter or review |
| Dale 1994 | Adults or unclear age |
| Dale 1997 | Editorial, letter or review |
| De Lorenzo 2012 | Duplicate publication |
| Demeyere 1992 | Mixed age but no paediatric data |
| Diaz‐Berenguer 1992 | Mixed age but no paediatric data |
| Dimatteo 2001 | Adults or unclear age |
| Dingle 2014 | Mixed age but paediatric data not extractable |
| DiNicola 1986 | RADT other than EIA or OIA |
| DuBois 1986 | RADT other than EIA or OIA |
| DuBose 1996 | Editorial, letter or review |
| Eaton 1987 | Editorial, letter or review |
| Edmonson 2003 | Duplicate publication |
| Edouard 2014 | Editorial, letter or review |
| Ehrlich 1993 | Reference standard not laboratory culture |
| Enright 2009 | Duplicate publication |
| Esteban 2004 | Editorial, letter or review |
| Fellah 1988 | RADT other than EIA or OIA |
| Figura 1981 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Fischer 1992 | Editorial, letter or review |
| Foong 1992 | Mixed age but no paediatric data |
| Fox 2006a | Reference standard not laboratory culture |
| Fox 2006b | Reference standard not laboratory culture |
| Frei 1991 | Editorial, letter or review |
| Fries 1995 | Reference standard not laboratory culture |
| Gaustad 1991 | Editorial, letter or review |
| Gerber 1986a | RADT other than EIA or OIA |
| Gerber 1989 | Editorial, letter or review |
| Gerber 1990a | RADT other than EIA or OIA |
| Gerber 1997a | Editorial, letter or review |
| Gerber 1997b | Editorial, letter or review |
| Gerber 1998 | Editorial, letter or review |
| Ghanassia 1996 | Editorial, letter or review |
| Gnehm 1987 | RADT other than EIA or OIA |
| Gonsu 2015 | Not ambulatory care setting |
| Greiver 1999 | Editorial, letter or review |
| Gupta 1992 | Target condition other than GAS |
| Gupta 1997 | Adults or unclear age |
| Gutman 1996 | Editorial, letter or review |
| Hadfield 1987 | RADT other than EIA or OIA |
| Hallander 1988 | Editorial, letter or review |
| Handrick 2006 | Editorial, letter or review |
| Hansen 1992a | RADT other than EIA or OIA |
| Hansen 1992b | Editorial, letter or review |
| Harbeck 1993 | Mixed age but no paediatric data |
| Harbeck 1995 | Editorial, letter or review |
| Hasin 1989 | Mixed age but no paediatric data |
| Haym 1986 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Hedges 1991 | Adults or unclear age |
| Heiter 1993 | Mixed age but no paediatric data |
| Heiter 1995 | Mixed age but no paediatric data |
| Hinfey 2010 | Mixed age but no paediatric data |
| Hodgins 1988 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Hoffmann 1987 | Editorial, letter or review |
| Hoffmann 1990 | Mixed age but no paediatric data |
| Holbrook 1998 | Editorial, letter or review |
| Hufnagel 2010 | Duplicate publication |
| Humair 2006 | Editorial, letter or review |
| Issa 2014 | Editorial, letter or review |
| Johansson 2003 | Mixed age but no paediatric data |
| Johnson 1995 | Editorial, letter or review |
| Joslyn 1995 | Mixed age but no paediatric data |
| Joubaud 2003 | Mixed age but no paediatric data |
| Kawakami 2003 | Mixed age but no paediatric data |
| Kayaba 1996 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Keahey 2002 | RADT other than EIA or OIA |
| Kechrid 1988 | RADT other than EIA or OIA |
| Kellogg 1986a | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Kellogg 1986b | Editorial, letter or review |
| Kellogg 1987 | Mixed age but no paediatric data |
| Kellogg 1988 | Mixed age but no paediatric data |
| Kellogg 1990 | Editorial, letter or review |
| Klein 1986 | Adults or unclear age |
| Kljakovic 2009 | Editorial, letter or review |
| Kojima 2002 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Kramer 1980 | Editorial, letter or review |
| Kurtz 1999 | Duplicate publication |
| Larkin 2001 | Editorial, letter or review |
| Laubscher 1994 | Editorial, letter or review |
| Lind 1988 | Editorial, letter or review |
| Lindbaek 2004 | Mixed age but no paediatric data |
| Lindsay 1985 | Editorial, letter or review |
| Llor 2009a | Editorial, letter or review |
| Llor 2009b | Mixed age but no paediatric data |
| Llor 2010 | Editorial, letter or review |
| Luebbert 1989 | Editorial, letter or review |
| Lutticken 1991 | Editorial, letter or review |
| Manasse 1989 | Adults or unclear age |
| Mateo 2010 | Duplicate publication |
| Mathur 1992 | Editorial, letter or review |
| Matthys 2006 | Editorial, letter or review |
| Mayefsky 1985 | Editorial, letter or review |
| McCusker 1984 | RADT other than EIA or OIA |
| Meier 1990 | RADT other than EIA or OIA |
| Messina 2010 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Morandi 2003 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Morandi 2010 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Morlan 1988 | RADT other than EIA or OIA |
| Nahata 1986 | Editorial, letter or review |
| Nerbrand 2002 | Mixed age but no paediatric data |
| Nissinen 2009 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Noorbakhsh 2011 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Norris 1993 | Editorial, letter or review |
| Omurzakova 2008 | Target condition other than GAS |
| Omurzakova 2009 | Target condition other than GAS |
| Omurzakova 2010 | Target condition other than GAS |
| Patel 1987 | Mixed age but no paediatric data |
| Penalba Citores 2007 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Petts 1985 | RADT other than EIA or OIA |
| Petts 1988 | RADT other than EIA or OIA |
| Pichichero 1992 | Editorial, letter or review |
| Portier 2003 | Editorial, letter or review |
| Prakash 1985 | Editorial, letter or review |
| Preston 1987 | Editorial, letter or review |
| Putto 1987 | RADT other than EIA or OIA |
| Radetsky 1985 | Editorial, letter or review |
| Radetsky 1987 | Editorial, letter or review |
| Raich 1990 | Mixed age but no paediatric data |
| Rasaiah 1986 | Editorial, letter or review |
| Raz 1987 | Editorial, letter or review |
| Razongles 1993 | RADT other than EIA or OIA |
| Redd 1988 | RADT other than EIA or OIA |
| Reed 1990 | Mixed age but no paediatric data |
| Reichardt 2009 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Rimoin 2004 | Duplicate publication |
| Roosevelt 2001 | Reference standard not laboratory culture |
| Santos 2003 | Not ambulatory care setting |
| Sarikaya 2010 | Adults or unclear age |
| Savoia 1992 | Not a RADT diagnostic study or 2 x 2 table not extractable |
| Schafer 1995 | Editorial, letter or review |
| Schmuziger 1996 | Mixed age but no paediatric data |
| Schmuziger 2003 | Mixed age but no paediatric data |
| Schwartz 1985 | RADT other than EIA or OIA |
| Seaberg 1997 | Mixed age but no paediatric data |
| Seecamp 1993 | Adults or unclear age |
| Seguido 1987 | RADT other than EIA or OIA |
| Seki 1986 | RADT other than EIA or OIA |
| Serra 1989 | Not ambulatory care setting |
| Shaughnessy 2015 | Editorial, letter or review |
| Sheeler 2002 | Adults or unclear age |
| Shekelle 1992 | Editorial, letter or review |
| Shriner 1985 | Editorial, letter or review |
| Shulman 1994 | Editorial, letter or review |
| Shulman 1995 | Editorial, letter or review |
| Skellern 1993 | Adults or unclear age |
| Smith 1989 | RADT other than EIA or OIA |
| Smith 1995 | Mixed age but no paediatric data |
| Solé 2009 | Editorial, letter or review |
| Stillstrom 1991 | Mixed age but no paediatric data |
| Stingu 2009 | Not ambulatory care setting |
| Supon 1998 | Mixed age but no paediatric data |
| Syriopoulou 2011 | RADT other than EIA or OIA |
| Taeron 2006 | Editorial, letter or review |
| Tagami 1997 | Target condition other than GAS |
| Tenjarla 1990 | Duplicate publication |
| Tocks 1992 | Editorial, letter or review |
| Todd 1987 | Editorial, letter or review |
| True 1986 | RADT other than EIA or OIA |
| Uhl 2003 | Mixed age but no paediatric data |
| Vakkila 2015 | RADT other than EIA or OIA |
| Waagepetersen 2009 | Editorial, letter or review |
| Wagener 1985 | RADT other than EIA or OIA |
| Warner 1985 | Editorial, letter or review |
| Waseem 2009 | Duplicate publication |
| Wegner 1992 | Mixed age but no paediatric data |
| Wegner 1996 | Editorial, letter or review |
| White 1986 | RADT other than EIA or OIA |
| Wolinsky 1986 | RADT other than EIA or OIA |
| Wong 2002 | Mixed age but no paediatric data |
| Woodburn 2007 | Mixed age but no paediatric data |
| Wright 1987 | RADT other than EIA or OIA |
| Yu 1988 | Adults or unclear age |
EIA: enzyme immunoassay GAS: group A streptococcus OIA: optical immunoassay RADT: rapid antigen detection test