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. 2019 Apr 10;5(4):eaaw1668. doi: 10.1126/sciadv.aaw1668

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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 2 — Hi-C maps [visualized with Juicebox (134)] of different species (24, 67, 75, 90, 135) showing more or less pronounced 3D partitioning of the genome. TADs are not obvious in Arabidopsis genome, but boundary-like regions and insulated genome units are discernible. In Drosophila, TADs are well demarcated and correlate well with the epigenetic landscape. A specific feature of mammalian TADs is the presence of “corner peaks,” i.e., peaks of interactions at the edges of TADs (indicated by black circles), revealing the presence of chromatin loops.