NCT02287207.

Trial name or title	Effects of transcranial direct current stimulation on fine motor skills in Parkinson's disease: a pilot study
Methods	Randomised cross‐over trial
Participants	Estimated enrolment: 20 Inclusion criteria: diagnosed with IPD according to the UK Brain Bank criteria; Hoehn and Yahr stage 2 in the on‐phase of medication cycle; right dominant PD Exclusion criteria: cognitive impairment (MMSE < 23); visuo‐spatial deficits (measured by the Rey‐Osterrieth Complex Figure (ROCF) test); left‐handedness (evaluated by Edinburgh Handedness scale); depression; pregnancy; alcohol abuse; aneurysm clips; pacemaker; neurostimulator; implemented defibrillator; magnetically activated implant or device; implemented pump; spinal cord stimulator; implemented hearing aid; artificial or prosthetic limb; metal parts in the body; any external or internal metal; artificial heart valve; other implants; history of brain surgery; migraine; family history of epilepsy; other contra‐indications for tDCS and transcranial magnetic stimulation; other neurological, psychiatric or interfering upper limb problems
Interventions	Each participant will undergo the following conditions: (A) A‐tDCS (1 mA; 20 minutes; treatment regimen not described) over M1 (length of resting period not stated) followed by S‐tDCS (20 minutes; treatment regimen not described) (B) S‐tDCS (20 minutes; treatment regimen not described) (length of resting period not stated) followed by A‐tDCS (1 mA; 20 minutes; treatment regimen not described) over M1
Outcomes	Outcomes will be recorded at baseline, at the end of intervention phase and at 1‐week follow‐up Primary outcome measures: Change in writing amplitude Change in writing velocity Secondary outcome measures: Change in speed on the Purdue Pegboard Test Change in cortical excitability Change in Short‐Latency Intracortical Inhibition Change in cortical silent period
Starting date	October 2015
Contact information	Alice Nieuwboer, Professor Sanne Broeder, Msc CatholicULeuven Leuven, Belgium, 3000
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