| 1 Catheter‐related BSI |
4 |
1436 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.64 [0.41, 0.99] |
| 1.1 Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution |
2 |
452 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.64 [0.32, 1.28] |
| 1.2 Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution |
2 |
503 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.77 [0.39, 1.53] |
| 1.3 Chlorhexidine in alcohol versus povidone‐iodine in alcohol |
1 |
481 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.40 [0.13, 1.24] |
| 2 Catheter‐related BSI per 1000 catheter‐days |
4 |
1450 |
Risk Ratio (Fixed, 95% CI) |
0.53 [0.30, 0.94] |
| 2.1 Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution |
1 |
308 |
Risk Ratio (Fixed, 95% CI) |
0.82 [0.23, 2.93] |
| 2.2 Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution |
3 |
661 |
Risk Ratio (Fixed, 95% CI) |
0.49 [0.25, 0.95] |
| 2.3 Chlorhexidine in alcohol versus povidone‐iodine in alcohol |
1 |
481 |
Risk Ratio (Fixed, 95% CI) |
0.41 [0.06, 2.92] |
| 3 All‐cause mortality |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.1 Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution |
1 |
213 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.15 [0.72, 1.83] |
| 3.2 Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution |
1 |
222 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.48, 1.34] |
| 4 Catheter colonisation |
5 |
1533 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.08 [‐0.12, ‐0.03] |
| 4.1 Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution |
2 |
452 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.09 [‐0.17, ‐0.02] |
| 4.2 Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution |
3 |
600 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.04 [‐0.11, 0.03] |
| 4.3 Chlorhexidine in alcohol versus povidone‐iodine in alcohol |
1 |
481 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.11 [‐0.17, ‐0.04] |
| 5 Catheter colonisation per 1000 catheter‐days |
5 |
1547 |
Risk Ratio (Fixed, 95% CI) |
0.64 [0.50, 0.81] |
| 5.1 Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution |
1 |
308 |
Risk Ratio (Fixed, 95% CI) |
0.69 [0.40, 1.20] |
| 5.2 Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution |
4 |
758 |
Risk Ratio (Fixed, 95% CI) |
0.64 [0.48, 0.85] |
| 5.3 Chlorhexidine in alcohol versus povidone‐iodine in alcohol |
1 |
481 |
Risk Ratio (Fixed, 95% CI) |
0.53 [0.24, 1.17] |
| 6 Insertion site infection |
1 |
242 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.80 [‐9.10, 3.50] |
