Study	Treatment	Efficacy outcomes at the end of treatment
Skrabek 2008	Nabilone 1 mg bid orally vs. placebo Titration from 0.5 mg to 1 mg bid from week 1 to 4	50% pain reduction: not reported and not provided on request PGIC: not assessed Pain: nabilone mean 4.8 (SD 2.2), placebo mean 5.7 (SD 1.8) * (P value = 0.02)*** Sleep: not assessed Fatigue: no significant difference ** Depression: no significant difference ** Anxiety: nabilone mean 4.3 (SD 1.8); placebo mean 4.9 (SD 2.2) * (P value < 0.01)*** Health‐related quality of life: mean 54 (SD 22.3); placebo mean 64 (SD 13.4) *; (P value < 0.01)***
Ware 2010	Nabilone 0.5 or 1 mg vs. amitriptyline 10 or 20 mg at bedtime each Titration in each of 2 periods of 2 weeks, with 2 weeks' washout between the 2 treatment periods	50% pain reduction: not reported and not provided on request PGIC: not assessed Mean pain intensity: no significant difference ** Sleep: nabilone: mean 9 (SD 10.8); amitriptyline mean 13 (SD 10.8) * Fatigue: not reported Depression: not reported Anxiety: not reported Health‐related quality of life: no significant difference **