| Methods |
Double‐blind, placebo‐controlled trial |
| Participants |
308 participants older than 2 years. Data from 283 participants included in analyses |
| Interventions |
Age‐adjusted oral penicillin, sulphadimidine or barium sulphate (placebo) administered for 5 days |
| Outcomes |
Incidence of rheumatic fever, otitis media and symptom of sore throat |
| Notes |
All groups received controlled doses of antipyretics twice daily for 3 days
Data from only 200 participants presenting with sore throat on day 1 included in sore throat analysis |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Participants randomised by random bottle dispensing |
| Allocation concealment (selection bias) |
Low risk |
|
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
|
| Selective reporting (reporting bias) |
Low risk |
All relevant outcomes reported |
