| Methods |
Randomised controlled trial |
| Participants |
1213 children aged 3 to 16 years. Suppurative complications occurring in participants in the control condition were treated with sulphonamides. Participants were excluded if they had a complication on admission |
| Interventions |
Intramuscular penicillin or no treatment for the controls |
| Outcomes |
Incidence of rheumatic fever |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Participants randomised by bed chart number |
| Allocation concealment (selection bias) |
High risk |
|
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
|
| Selective reporting (reporting bias) |
Unclear risk |
Antipyretic use was not documented |
