Troy 2014.
Methods | Double blind, placebo controlled, randomised crossover study | |
Participants | Six participants with IPF, resting normoxia and exercise desaturation. Exclusion criteria were resting hypoxaemia and an inability to complete exercise testing | |
Interventions | Supplemental oxygen (60% for cardiopulmonary exercise testing, 3 L/min for endurance walk (delivered via light‐weight cylinder)) compared to medical air | |
Outcomes | Cardiopulmonary exercise test and distance at endurance shuttle walk test (ESWT) (m) | |
Notes | Conducted in hospital respiratory physiology laboratory in Sydney, Australia | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Sequence generation was unclear: "subjects completed two shuttle endurance walk tests randomised to 3L/min oxygen or medical air in a randomised cross‐over double blinded fashion." |
Allocation concealment (selection bias) | Low risk | Crossover design negates this |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | The study authors reported double blinding (see above) |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | The ESWT is a standardised test. The trial authors did not explicitly state that they performed blinding |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All participants completed the study |
Selective reporting (reporting bias) | Low risk | The study authors reported all data |
Abbreviations: IPF: idiopathic pulmonary fibrosis; ESWT: endurance shuttle walk test; 6MWT: 6‐minute walk test; L/min: litres per minute.