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. 2016 Jul 6;2016(7):CD011716. doi: 10.1002/14651858.CD011716.pub2

Troy 2014.

Methods Double blind, placebo controlled, randomised crossover study
Participants Six participants with IPF, resting normoxia and exercise desaturation. Exclusion criteria were resting hypoxaemia and an inability to complete exercise testing
Interventions Supplemental oxygen (60% for cardiopulmonary exercise testing, 3 L/min for endurance walk (delivered via light‐weight cylinder)) compared to medical air
Outcomes Cardiopulmonary exercise test and distance at endurance shuttle walk test (ESWT) (m)
Notes Conducted in hospital respiratory physiology laboratory in Sydney, Australia
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Sequence generation was unclear: "subjects completed two shuttle endurance walk tests randomised to 3L/min oxygen or medical air in a randomised cross‐over double blinded fashion."
Allocation concealment (selection bias) Low risk Crossover design negates this
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk The study authors reported double blinding (see above)
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk The ESWT is a standardised test. The trial authors did not explicitly state that they performed blinding
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All participants completed the study
Selective reporting (reporting bias) Low risk The study authors reported all data

Abbreviations: IPF: idiopathic pulmonary fibrosis; ESWT: endurance shuttle walk test; 6MWT: 6‐minute walk test; L/min: litres per minute.