Comparison 8. Morbidity: clinical outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Cardiac events	9	4849	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.79, 1.39]
2 Myocardial infarction	16	8303	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.74, 1.60]
3 Congestive heart failure	12	6257	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.45, 1.35]
4 Cerebrovascular accident (CVA) ‐ stroke	13	7343	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.53, 1.14]
5 Rebleeding	6	3108	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.51, 1.10]
6 Sepsis/bacteraemia	7	3963	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.79, 1.35]
7 Pneumonia	14	6277	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.80, 1.11]
8 Pneumonia or wound infection	14	9574	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.86, 1.07]
9 Thromboembolism	10	4019	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.76 [0.40, 1.45]
10 Renal failure	10	5929	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.92, 1.18]
11 Mental confusion	6	1344	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.65, 1.30]