Cooper 2011.

Methods	Randomised clinical trial
Participants	45 participants with acute myocardial infarction and haematocrit less than 30% Liberal: n = 21; mean (SD) age = 76.4 (13.5) years Restrictive: n = 24; mean (SD) age = 70.3 (14.3) years
Interventions	Liberal transfusion: transfusion occurred when haematocrit < 30% to maintain 30% to 33%. Conservative transfusion: transfusion occurred when haematocrit < 24% to maintain 24% to 27%.
Outcomes	The primary clinical safety measurements were in‐hospital death, recurrent myocardial infarction, or new or worsening congestive heart failure.
Notes	‐
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	The paper did not describe random sequence generation.
Allocation concealment (selection bias)	Low risk	The trial used consecutively numbered opaque envelopes.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Participants and investigators were not blinded.
Blinding of outcome assessment (detection bias) All outcomes	High risk	A local investigator determined the outcomes.
Incomplete outcome data (attrition bias) All outcomes	Low risk	There was complete in‐hospital follow‐up. 3 of 45 participants were lost to follow‐up at 30 days.
Selective reporting (reporting bias)	Low risk	No reporting bias was apparent.
Other bias	Low risk	No other biases identified.