Lacroix 2007.

Methods	Randomised controlled trial
Participants	637 stable critically ill children with Hb concentrations below 9.5 g/dL within 7 days after admission to an ICU were randomly allocated to 1 of 2 groups: Liberal group: n = 317; M/F = 191/126; mean (SD) age = 39.6 (51.9) months The restrictive group: n = 320; M/F = 190/130; mean (SD) age = 35.8 (46.2) months
Interventions	The liberal group were transfused RBC when the Hb concentration fell below 9.5 g/dL, with a target range of 11.0 g/dL to 12.0 g/dL. The restrictive group were transfused RBC if the Hb concentration dropped below 7.0 g/dL, with a target range of 8.5 g/dL to 9.5 g/dL.
Outcomes	28‐day mortality, sepsis, transfusion reactions, infections, length of stay
Notes	‐
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	The trial reported no information regarding this domain.
Allocation concealment (selection bias)	Low risk	Allocation was internet‐based and central.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Clinical staff and parents of the participants were aware of the assignments to study groups.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Mortality was the primary outcome.
Incomplete outcome data (attrition bias) All outcomes	Low risk	There were very few dropouts.
Selective reporting (reporting bias)	Low risk	No reporting bias was apparent.
Other bias	Low risk	No other biases were apparent.