Villanueva 2013.

Methods	Randomised clinical trial
Participants	Participants older than 18 years of age who had haematemesis or melena, or both (due to upper GI bleeding) Liberal: n = 445; mean age (SD) = 64 (16) years Restrictive: n = 444; mean age (SD) = 66 (15) years
Interventions	The restrictive transfusion group was transfused for haemoglobin < 7 g/dL, and the liberal transfusion group was transfused when Hg was < 9 g/dL. In both groups, 1 unit of RBCs was transfused initially.
Outcomes	Death at 45 days
Notes	‐
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random sequence generation was computer generated.
Allocation concealment (selection bias)	Low risk	The trial used sealed consecutively numbered, opaque envelopes.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Clinicians and participants were not blinded.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Mortality was the primary outcome. Assessors of other outcomes were not documented to be blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	The trial had good follow up.
Selective reporting (reporting bias)	Low risk	Reporting was complete.
Other bias	Low risk	No other biases were apparent.