Webert 2008.

Methods	Randomised controlled trial
Participants	60 adult participants with acute leukaemia were randomly allocated to 1 of 2 groups: Liberal group: n = 31; M/F = 14/17; mean (SD) age = 45.3 (16.8) years Restrictive group: n = 29; M/F = 1811; mean (SD) age = 50.8 (15.3) years
Interventions	The liberal group were transfused 2 units of RBC when the Hb concentration fell below 12.0 g/dL. The restrictive group were transfused 2 units of RBC if the Hb concentration dropped below 8.0 g/dL, with a target range of 85 to 95 g/dL.
Outcomes	Transfusions, bleeding risk, 30‐day mortality provided by authors
Notes	‐
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Sequence generation was computer‐generated.
Allocation concealment (selection bias)	Low risk	Allocation was internet‐based and central.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Participants and clinicians were not blinded.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcomes were assessed blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	There were no missing data.
Selective reporting (reporting bias)	Low risk	No reporting bias was apparent.
Other bias	Low risk	No other biases were apparent.

Abbreviations

ACS = acute coronary syndrome
 ARDS = acute respiratory distress syndrome
 CARE = Cardiac Anesthesia Risk Evaluation
 DSMB = Data Safety Monitoring Board
 GI = gastrointestinal
 Hb = haemoglobin
 Hct = haematocrit
 ICU = intensive care unit
 IHD = ischaemic heart disease
 M/F = male/female
 PLTs = platelets
 RBC = red blood cells
 SD = standard deviation
 TKA = total knee arthroplasty