Camus 1975.

Methods	RCT, DB, parallel groups Duration 10 days
Participants	Musculoskeletal pain (eg tendon, muscle, or ligament injury) Patients had moderate or mild pain N = 20 M = 8, F = 12 Age range 19 ‐ 86 years
Interventions	Diethylamine salicylate (10%), myrtecaine (1%) cream (Algesal Suractive), n = 10 Placebo cream, n = 10 x 3 daily at the site of pain
Outcomes	PI at rest: 4‐point scale Functional limitation: 5‐point scale Presence of spontaneous pain, swelling, heat Composite score based on above (20 points) Improvement in: PI at rest, Composite score
Notes	Oxford Quality Score: R1, DB2, W0. Total = 3/5 Myrtecaine (Nopoxamine) is a local anaesthetic agent
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method used to generate random sequence not described
Allocation concealment (selection bias)	Unclear risk	Method not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Method not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed study
Size	High risk	< 50 participants per treatment arm