Ibanez 1988.

Methods	RCT, DB, active control, parallel group Duration 12 days Assessment on days 4, 8, 12
Participants	Slight articular and extra‐articular sports injuries in last 24 h N = 137 Average age 23 years (range 13 ‐ 59)
Interventions	Benzydamine salicylate (6%) spray (Benzasal), n = 35 Fepradinol (6%) spray (Dalgen), n = 102 One spray x 4 daily
Outcomes	PI on passive movement: 5‐point scale PI on active movement: 5‐point scale Inflammation: 5‐point scale Functional limitation: 5‐point scale Time to cure Adverse events
Notes	Oxford Quality Score: R1, DB1, W0. Total = 2/5 Baseline scores for inflammation differed between the two groups Fepradinol is an NSAID
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method used to generate random sequence not described
Allocation concealment (selection bias)	Unclear risk	Method not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Method not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No data on withdrawals or dropouts, or method of imputation
Size	High risk	< 50 participants per treatment arm