Beenen 2014.

Study characteristics
Patient sampling	Sample size: 131 Females: Not stated Age: Not stated
Patient characteristics and setting	Patients with CT and ultrasound resectable periampullary cancer Setting: Secondary/tertiary care, the Netherlands
Index tests	Diagnostic laparoscopy Criteria for positive diagnosis: Biopsy confirmation of suspicious lesions
Target condition and reference standard(s)	Target condition: Unresectability Reference standard: Laparotomy Criteria for positive diagnosis: Locally advanced pancreatic cancer or metastatic pancreatic cancer
Flow and timing	Number of indeterminates for whom the results of reference standard were available: 0 Number of patients who were excluded from the analysis: 74 (36.1%)
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	No
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		High	High
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	No
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Unclear
Were the reference standard results interpreted without knowledge of the results of the index tests?	No
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
		High