| Methods | Cohort study | |
| Participants | Participants residents in the great Gothenburg area (Sweden) born between 1959 and 1990 | |
| Interventions | Different vaccination programmes carried out from 1971 with different vaccines (single‐component measle, mumps and rubella vaccine so as with MMR vaccine) having as target population children of different ages | |
| Outcomes | Incidence of multiple sclerosis (MS, 4 Poser's criteria) and Clinically Isolated Syndrome (CIS) with onset between 10 and 39 years of age was assessed in birth cohorts immunised within 4 vaccination programmes | |
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | High risk | Not applicable |
| Allocation concealment (selection bias) | High risk | Not applicable |
| Blinding (performance bias and detection bias) All outcomes | High risk | Not applicable |
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