2. Details on RCTs assessing vaginal dryness requiring additional data or analysis before data synthesis.

Study	Comparator	Outcome measure	Information available	Method used	Results for meta‐analysis	SMD
Hudita 2003	Placebo (3‐arm study)	0 to 4 scale	From figure Week 24 P: 2.6 T 1.25 mg: 1 T 2.5 mg: 0.9 N = 34/2 = 17 N = 45 N = 41	Split control group size between 2 arms Use known value from other study for SD Use those from Nappi 2006a SD T: 0.89 HT: 0.89	Mean P: 2.6 T 1.25 mg: 1 T 2.5 mg: 0.9 N N = 34/2 = 17 N = 45 N = 41 SD P: 0.89 T 1.25: 0.89 T 2.5: 0.89	1.25mg SMD: ‐1.7751711 SE: 0.3262804 2.5mg SMD: ‐1.8843965 SE: 0.3373802
Kenemans 2009	Placebo	Vaginal dryness as binary	P: 33/1558 T: 19/1575	Convert OR to SMD	P: 33/1558 T: 19/1575
Swanson 2006	Placebo (3‐arm study)	0 to 3 score	Mean change from baseline at week 12 P: ‐0.2 T 2.5: ‐0.26 T 1.25: ‐0.39 N P: 133 T 2.5: 125 T 1.25: 133	Split control group size between 2 arms Calculate final means using baseline and change – but no baseline values given Would also need to use SDs from another study	Cannot use
Huber 2002	HT	Vaginal dryness as binary	HT: 7/166 T: 6/158	Convert OR to SMD	HT: 7/166 T: 6/158	SMD: ‐0.06613757 SE: 0.34411866
Kokcu 2000	HT	Vaginal dryness as binary	HT: 0/21 T: 1/23	Convert OR to SMD	HT: 0/21 T: 1/23	SMD: 0.6382727 SE: 1.0064298
Ziaei 2010	HT and placebo	Vaginal dryness as binary Also, lubrication scores 1 to 5, higher is better – can reverse signs of mean differences	HT: 20/42 T: 33/47 P: 37/48 Mean HT: 4.93 T: 4.58 P: 3.65 SD HT: 1.95 T: 1.26 P: 1.81	Use the continuous data Calculate and reverse sign, so that greater = increased vaginal dryness	HT: 20/42 T: 33/47 P: 37/48	Using OR to SMD vs HT SMD: 0.5774306 0.2691251 vs placebo SMD ‐0.5904427 SE: 0.2096301 Using lubrication scores vs HT: SMD after switching sign: 0.2138954 SE: 0.2129393 vs placebo: SMD after switching sign: ‐0.1313959 SE: 0.2185150
Nappi 2006a	HT	Vaginal dryness 0 to 3 score	From Figure 4, mean at 6 months Mean T: 0.7 HC: 0.6 SD: can read SE off Figure 4 and calculate SD N = 20 both groups	SD: can read SE off Figure 4 and calculate SD T: 0.89 HT: 0.89	Mean T: 0.7 HC: 0.6 SD T: 0.89 HT: 0.89 N = 20	SMD: 0.1101248 SE: 0.3164674
Uygur 2005	HT	7‐point scale with ‐3 as worsened a lot and 3 as improved a lot	6 months Mean (higher is better) HT: 0 T: 0.56 N HT: 34 T: 38	P < 0.05 given. Assume P = 0.05 and calculate SD, assuming equal in 2 groups: Gives SD = 1.7	Mean (higher is better) HT: 0 T: 0.56 N HT: 34 T: 38 Sd=1.7 for both	SMD after sign change: ‐0.3258676 0.2376236