Benedek‐Jaszmann 1987.

Methods	Parallel‐group RCT
Participants	60 healthy postmenopausal women 44 to 61 years old, with hot flushes, who had undergone natural or surgical menopause and were experiencing hot flushes and associated symptoms
Interventions	Tibolone 2.5 mg/d Placebo 1 tablet/d Administered for 1 year
Outcomes	Hot flushes, insomnia Following scoring system used for clinical parameters: absent = 0, mild = 1, moderate = 2, strong = 3
Notes	Menopausal symptoms measured on a non‐validated scale Timing: unclear Trial location: Netherlands Multi‐centre: no; single site
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Study authors state that the trial is double‐blind and that identical‐looking placebo tablets have been used
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Outcomes evaluated through a questionnaire with insufficient information to judge whether outcome measurement could have been influenced
Incomplete outcome data (attrition bias) All outcomes	High risk	17/60 participants dropped out. Unclear how many were randomised to each group
Selective reporting (reporting bias)	Unclear risk	Study protocol not available
Conflict of interest	Unclear risk	No information provided